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LBH589

10 mg

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Cat No. 16-K74

Availability: In stock

$99.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

LBH589 (Panobinostat) is a novel HDAC inhibitor that has been shown to induce acetylation of histone H3 and H4, increase p21 levels and disrupt the chaperone function of hsp90. LBH589 induces G(2) M Cell cycle arrest and inhibits HUVEC proliferation and viability. At noncytotoxic concentrations. LBH589 inhibits AKT activity, endothelial tube formation and Matrigel invasion.

LBH589

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TECHNICAL INFORMATION

Other Names: Faridak, Panobinostat, NVP-LBH-589

Chemical Formula: C21H23N3O2

CAS Number: 404950-80-7

Molecular Weight: 349.43

Purity:  >98%

Appearance:  a crystalline solid  

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO at 200 mg/ml. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.

 

References

 

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