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LDN193189

2 mg

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Cat No. 36-F52

Availability: In stock

Regular Price: $219.00

Special Price: $119.00

Bulk Quantities Available

All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

LDN193189 is a highly potent small molecule BMP inhibitor. It inhibits BMP type I receptors ALK2, ALK3 and ALK6. LDN193189 was derived from structure-activity relationship studies of Dorsomorphin and functions by preventing phosphorylation of Smad1, Smad5 and Smad8. It shows in vivo clinical utility by reducing ectopic ossification in mouse models. 


 

LDN193189

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TECHNICAL INFORMATION

Other Names: DM-3189, 6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine hydrochloride

Chemical Formula: C₂₅H₂₂N₆ HCl

CAS Number: 1062368-24-4 

Molecular Weight: 442.94

Purity:  99% pure

Appearance: Yellow/Orange Powder

Solubility: DMSO and methanol

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. For a 10mM concentrated stock solution, reconstitute the compound by adding 452 µl of DMSO to the entire contents of the vial. Vortex for 5 minutes.

 

 

 

References

 

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