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Roscovitine

1mg

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Cat No. 34-K14

Availability: In stock

$29.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

Roscovitine, also known as Seliciclib or CYC202, is a potent and reversible inhibitor of select cyclin-dependent kinases (CDKs), CDK1, CDK2, and CDK5. It has less sensitivity towards related kinases including ERK1,2. This molecule competes for the binding site of ATP in the catalytic cleft. Treatment of cultured cells with roscovitine can cause cell cycle arrest or apoptosis.

Roscovitine

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TECHNICAL INFORMATION

Other Names: 6-Benzylamino-2[(R)-(1’-ethyl-2’-hydroxyethylamino)]-9-isopropylpurine

Chemical Formula: C19H26N6O

CAS Number: 186692-46-6

Molecular Weight: 354.45

Purity: >99%

IC50= CDK2: .1µm, CDK5: .16µm

Appearance: Crystalline Solid

Solubility: DMSO (100mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO.

 

References

 

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