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SB202190

5 mg

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Cat No. 42-F97

Availability: In stock

$59.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

SB202190 is a pyridinyl imidazole that inhibits p38 kinase in vivo through competition with ATP. It binds within the ATP pocket of the active kinase and selectively inhibits p38α and β isoforms. SB202190 induces apoptosis through the activation of cysteine protease (CPP32) like kinases.  SB202190 has been shown to block both lipopolysaccharide (LPS) induced gene expression and nitric oxide (NO) induced stabilization of interleukin (IL) -8 mRNA in monocytes. 


 

SB202190

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TECHNICAL INFORMATION

Other Names: 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole

Chemical Formula:  C20H14FN3O

CAS Number: 152121-30-7

Molecular Weight: 331.34

Purity:  >98%

Appearance:  off white solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO at 30mg/ml.  If precipitate is observed,  vortex for 5 minutes.

 

 

References

 

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