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Vandetanib

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  1. Vandetanib
    Vandetanib
    $99.00

    Vandetanib is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor. It has been shown to inhibit VEGFR-dependent tumor angiogenesis and EGFR– and RET-dependent tumor cell proliferation and survival.  Vandetanib has also been shown to inhibt fms-like tyrosine kinase 4  (VEGFR3, IC50 = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC50 = 500 nM) but shows selectivity relating to a range of other tyrosine and serine-threonine kinases. 

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