Reagents Direct

direct results now

Skip to Main Content »

Your shopping cart is empty

XAV939

5 mg

Be the first to review this product

Cat No. 52-A47

Availability: In stock

$99.00

Bulk Quantities Available

All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

OR

Description

XAV939 is a cell permeable, small molecule inhibitor of the Wnt/β– catenin pathway. It inhibits tankyrase 1 (IC₅₀= 11nM)and tankyrase 2 (IC₅₀=4nM), stabilizes axin and stimulates β-catenin degradation.  Small molecule XAV939 has also been shown to inhibit proliferation of the µ-catenin-dependent colon carcinoma cell line DLD-1.


 

XAV939

Double click on above image to view full picture

Zoom Out
Zoom In

More Views

Details

TECHNICAL INFORMATION

 Other Names: 3,​5,​7,​8-​tetrahydro-​2-​[4-​(trifluoromethyl)phenyl]-​4H-​thiopyrano[4,​3-​d]pyrimidin-​4-​one

Chemical Formula: C14H11F3N2OS

CAS Number: 284028-89-3

Molecular Weight: 312.3

Purity:  >98%

Appearance: Crystalline solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO (50mM). For most cells, the maximum tolerance to DMSO is <0.5%.   

 

References

 

Tech Docs