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AT9283

2mg

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Cat No. 64-Q25

Availability: In stock

$100.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

AT9283 is a multi-targeted kinase inhibitor of both Aurora kinases (A & B) as well as Janus kinase (Jak) 2. It also targets serine/threonine protein kinases associated with myeloid cell proliferation. AT9283 inhibited growth and survival of multiple solid tumor cell lines.

AT9283

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TECHNICAL INFORMATION

Other Names: 1-cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea

Chemical Formula: C19H23N7O2

CAS Number: 896466-04-9

Molecular Weight: 381.43

Purity: >98%

IC50= Aurora A: 3nM, Aurora B: 3nM, JAK2: 1.2nM

Appearance: Powder

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 76mg/ml

 

References

 

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