Other Names: (S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Chemical Formula: C14H14CIFN8
CAS Number: 935666-88-9
Molecular Weight: 348.77
IC50= JAK1=1.3nM, JAK2=.26nM
Appearance: Off-White Powder
STORAGE AND HANDLING
Storage: Store at 4°C and protected from light. Following reconstitution, store aliquots at -20°C.
Stability: Stock solutions stable at -20°C for up to 2 years.
Shipping Conditions: Shipped at room temperature.
Soluble in DMSO. Soluble at 70mg/ml
Loveless, M.E., et al (2012). Comparisons of the efficacy of a JAK 1/2 inhibitor (AZD1480) with a VEGF signaling inhibitor (Cediranib) and sham treatments in mouse tumors using DCE-MRI, DW-MRI, and histology. Neoplasia. 14:54-64.