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WP1066

10mg

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Cat No. 76-J32

Availability: In stock

$115.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

WP1066 is a Janus kinase (Jak) 2 inhibitor. It works by degrading the Jak2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to result in the activation of the caspase pathway. The Jak/STAT pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals. In mammals, it is the principal signaling mechanism for a wide array of cytokines and growth factors. WP1066 also acts as an immune adjuvant by inducing proliferation of effector T cells and upregulating CD86 and CD80.

WP1066

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TECHNICAL INFORMATION

Other Names: (S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamine

Chemical Formula: C17H14BrN3O

CAS Number: 857064-38-1

Molecular Weight: 356.22

Purity: >99%

IC50= JAK2= 2.3µm, Stat3= 2.43µm

Appearance: Off-White Solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 71mg/ml

 

References

 

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