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DAPT

5 mg

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Cat No. 47-T13

Availability: In stock

$89.00

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All Reagents Direct products are for laboratory research use only at a qualified research institution, and are not for private individual, patient nor veterinary use.

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Description

DAPT is a γ-secretase inhibitor that indirectly inhibits Notch, a γ-secretase substrate. Since Notch is involved in the development of the nervous system and pancreas, DAPT has been suggested to be used in the modulation of Notch activity in embryonic stem cell differentiation. As an inhibitor of γ-secretase, DAPT may also be useful in the study of β-amyloid (Aβ) formation.


 

DAPT

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TECHNICAL INFORMATION

Other Names: N-[(3,5-Difluorophenyl)acetyl]-L-al
anyl-2-phenyl]glycine-1,1-dimethylethyl ester, LY-374973

Chemical Formula: C23H26F2N2O4

CAS Number: 208255-80-5 

Molecular Weight: 432.46

Purity:  >98%

Appearance:  a crystalline solid  

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. For a 10mM concentrated stock solution, add 1.16 ml to the entire contents of the vial. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%. 

 

References

 

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