Trichostatin A (TSA)

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Quick Overview

Trichostatin A is a selective and potent inhibitor of histone deacetylase (HDAC). It selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, resulting in chromatin relaxation and modulation of gene expression. Trichostatin A has been shown to inhibit both the G1- and G2– phases of the mammalian cell cycle and has been used to induce apoptosis in cancer cells with low toxicity to non-cancer cells.