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Quick Overview

PS48 is an allosteric small molecule activator of phosphoinositide-dependent protein kinase 1 (PDK1) that binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of the only allosteric compounds that targets a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlaps with the ATP binding site. PS48 has been shown to enhance reprogramming of neonatal human epidermal keratinocytes (NHEKs).