A-922500

5 mg

Cat. No.: 44-K21

$150.00

A-922500 is a diacylglycerol acyltransferase 1 (DGAT-1) inhibitor for both human and mouse. DGATs catalyze the final reaction step in the synthesis of triglyceride.

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Details

TECHNICAL INFORMATION

Other Names: (1R,2R)-2-(4′-(3-phenylureido)biphenylcarbonyl)-cyclopentanecarboxylic acid

Chemical Formula: C26H24N2O4

CAS Number: 959122-11-3

Molecular Weight: 428.5

Purity: >95%

IC50= 22.0 nM

Appearance: White Solid

Solubility: DMSO (100mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 20mg/ml

References

King | A.J. | et al. (2010) In vivo efficacy of acyl CofA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia. Eur J Pharmacol. 637:155-61.

King | A.J. | et al. (2009) Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the Zucker fatty rat and the hyperlipidemic hamster. J Pharmacol Exp Ther. 330:526-31.

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