CH5424802

5 mg

Cat. No.: 73-P27

$180.00

CH5424802, also known as AF802, is a potent and selective Anaplastic lymphoma kinase (ALK) inhibitor. ALK is a tyrosine kinase that is constitutively activated in certain cancers, following gene alterations such as chromosomal translocation, amplification, or point mutation. It has shown limited inhibition of other kinases, GAK and LTK. LTK is known to show greatest sequence similarity to ALK.

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Details

TECHNICAL INFORMATION

Other Names: 9-Ethyl-6,6-Dimethyl-8-[4-(Morpholin-4-YI)piperodin-1-YI]-11-Oxo-6,11-Dihydro-5h-Benzo[b]carbazole-3-Carbonitrile

Chemical Formula: C30H34N4O2

CAS Number: 1256580-46-7

Molecular Weight: 482.62

Purity: >99%

IC50= 3nM

Appearance: White Powder

Solubility: DMSO (100mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 20mg/ml

References

Kinoshita | K. | et al. (2012). Design and synthesis of a highly selective | orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802). Bioorg Med Chem. 20:1271-80.

Sakamoto | H. | et al (2011). CH5424802 | a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell. 19:679-90.

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