Dexamethasone

100mg

Cat. No.: 58-I55

$35.00

Dexamethasone, a synthetic glucocorticoid with a higher affinity than a natural ligand, cortisol, has a range of effects on cell survival, cell signaling and gene expression. It is know to affect inflammatory responses, cellular proliferation, and differentiation in target tissues. Dexamethasone has been shown to inhibit differentiation of cord blood stem cell derived dendritic cells (DC) precusors into immature DCs.

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Details

TECHNICAL INFORMATION

Other Names: 9-fluoro-11b,17a,21-trihydroxy-16-methyl-pregna-1,2-diene-3,20-dione

Chemical Formula: C22H29FO5

CAS Number: 50-02-2

Molecular Weight: 392.50

Purity: >99%

IC50= 5nM

Appearance: White Solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 79mg/ml

References

Claessens | S.E. | et al (2012). Acute effects of neonatal dexamethasone treatment on proliferation and astrocyte immunoreactivity in hippocampus and corpus callosum: Towards a rescue strategy. Brain Res. 10.1016.

Menshanov | P.N. | et al (2012). Effects of dexamethasone on the development of neonatal rats and level of active caspase-3 in brain cortex. Bull Exp Biol Med. 153:478-80.

Brust | J.C. | et al (2012). Meningococcal meningitis | dexamethasone | and class III evidence. Neurology. 10.1212.

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