GDC0449 (Vismodegib)

5 mg

Cat. No.: 17-G94

$99.00

GDC0449 is a potent hedgehog (Hh) signaling pathway inhibitor with an IC₅₀ of 3nM.  The Hedgehog signaling pathway plays an important role in tissue growth and repair. GDC0449 works by blocking the activities of the Hedgehog-ligand cell surface receptors PTCH or SMO and suppresses Hedgehog signaling. It has been shown to inhibit the growth of primary pancreatic xenographs without non-specifically inhibiting pancreatic cell proliferation in vitro. GDC0449 has also been shown to inhibit ABCG2, Pgp, and MRP1-important ABC transporters associated with MDR. It has also been used to treat medullablastoma in animal models.

 

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TECHNICAL INFORMATION

Other Names: GDC-0449, Vismodegib, HhAntag691 

Chemical Formula:  C19H14Cl2N2O3S

CAS Number: 879085-55-9

Molecular Weight: 421.30

Purity:  >99%

Appearance:  crystalline solid 

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO at 200mg/ml. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.

 

References

Rudin et al. (2009) Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med. 361(12):1173-8.

Zhang et al. (2009) Hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp. Neoplasia. 11(1):96-101.

Giannetti et al. (2011) Identification | characterization | and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449). J Med Chem. 54(8):2592-601.

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