IPA3

5mg

Cat. No.: 51-N19

$75.00

IPA3 is a selective inhibitor of P21-activated kinase (PAK1). It functions by targeting the autoregulatroy mechanism, inhibiting the activators from binding to the active sites on the enzyme, producing the inactive conformation of PAKs. The autoinhibitory regions suppress the catalytic activity of its kinase domain, which are removed once activators have bound to the protein. IPA2 does not inhibit PAK1 if activators are already bound to the enzyme. PAK1 is implicated in tumorigenisis and metastasis.

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Details

TECHNICAL INFORMATION

Other Names: 1,1’-Disulfanediyldinaphthalen-2-01

Chemical Formula: C20H14O2S2

CAS Number: 42521-82-4

Molecular Weight: 350.45

Purity: >97%

IC50= PAK1 2.5µM

Appearance: Off White-Yellow Powder

Solubility: DMSO (75mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 75mM

References

Singhal | R. | et al (2012). The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in VRAF and Ras oncogenes. Oncotarget. 3:700-8.

Wang | Z. | et al (2011). Inhibition or ablation of P21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo. J Biol Chem. 286:41359-67

Hoover | W.C. | et al (2012). Inhibition of P21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways. PLos One. 7:e42601.

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