Nilotinib

Cat. No.: 66-J40-500

$640.00

Nilotinib, also known as AMN107 or Tasigna, is a tyrosine kinase inhibitor. It is an analog of imatinib with similar multiple kinase targets, but without inhibition of the Src gene. This gene regulates tyrosine kinase proteins that in turn affect whether cells multiply or die. Tyrosine kinase inhibitors interfere with cell communication and growth. Nilotinib is a selective BCR-ABL inhibitor that fits into the ATP-binding site of the BCR-ABL protein. It has a higher affinity for the BCR-ABl protein than imatinib. It is not only more potent than imatinib against wild-type BCR-ABL (IC50 < 30 nM), but also significantly active against 32/33 imatinib-resistant BCR-ABL mutants. Nilotinib was as potent as imatinib in inducing apoptosis (IC50 = 0.54 nM) and inhibiting proliferation (IC50 = 0.20 nM) of EOL-1 cells.

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TECHNICAL INFORMATION

Other Names: 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide

Chemical Formula: C28H22F3N7O

CAS Number: 641571-10-0

Molecular Weight: 529.52

Purity: >98%

IC50= 12nM

Appearance: Crystalline Solid

Solubility: DMSO (100mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 20mg/ml

References

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Product Specifications

MSDS