NKH477

5mg

Cat. No.: 50-M87

$79.00

NKH477 is a water-soluble analog of forskolin. Like forskolin, NKH477 activates adenylyl cyclases without altering the activity of phosphodiesterases or sodium/potassium ATPases. This compound stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms. It dose dependently increases cAMP and blocks potassium-induced contraction concetrations in smooth muscle strips (IC50 = 80 nM). NKH 477 causes relaxation of histamine treated guinea pig smooth muscle (IC50 = 32 nM).

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TECHNICAL INFORMATION

Other Names: (3R, 4aR, 5S, 6S, 6aS, 10S, 10aR, 10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10, 10b-dihydroxy-3, 4a,7, 7, 10a-pentamethyl-β-alanine, N, N-dimethyl-oxo-1H-naphtho[2,1-b]pyran-6-yl ester, monohydrochloride

Chemical Formula: C27H43NO8–HCL

CAS Number: 138605-00-2

Molecular Weight: 546.10

Purity: >98%

Appearance: White Crystalline Solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO

References

Nakashima | S. | et al (2005). Antiproliferative effects of NKH477 | a Forskolin derivative | on cytokine profile in rat lung allografts. J Heart Lung Transplant. 24:462-9.

Oishi | H. | et al (2012). Olprinone and colforsin daropate alleviate septic lung inflammation and apoptosis through CREB-independent activation of the AKT pathway. Am J Physiol Cell Mol Physiol. 303:L130-40.

Suzuki | S. | et al (2012). Intraarterial colforsin may improve the outcome of pateints with aneurysmal subarachnoid hemorrhage: a restrospective study. World Neursurg. 78:295-9.

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