NSC74589

5mg

Cat. No.: 18-N27

$65.00

NSC74859, also known as S3I-201, binds the Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription, therefore, inhibiting growth and inducing apoptosis preferentially in tumor cells that contain persistently activated Stat3. Moreover, NSC74859 also inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin.

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Details

TECHNICAL INFORMATION

Other Names: 2-hydroxy-4(2-(tosyloxy)acetamido)benzoic acid

Chemical Formula: C16H15NO7S

CAS Number: 501919-59-1

Molecular Weight: 365.36

Purity: >98%

IC50= 86µM

Appearance: Light Beige Solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 73mg/ml

References

Hu | Q.D. | et al (2012). NSC74859 enhances doxorubicin cytotoxicity via inhibition of epithelial-mesenchymal transition in hepatocellular carcinoma cells. Cancer Lett. 28:207-13.

Chen | W. | et al (2012). NSC74589-mediated inhibition of STAT3 enhances the anti-proliferative activity of cetuximab in hepatocellular carcinoma. Liver int. 32:70-7.

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