PP242

5 mg

Cat. No.: 26-Q09

$69.00

PP242 is a potent and selective inhibitor of mTOR, inhibitor, a Ser/Thr kinase  and cell growth controller.  PP242, but not Rapamycin has been shown to induce cell death in mouse and human leukemia cells in vitro.  In vivo, PP242 delayed leukemia onset and enhanced the effects of the front-line tyrosine kinase inhibitors more effectively than rapamycin. PP242 has also been shown to significantly augment histone deacetylase inhibitor-induced apoptosis in hepatocellular carcinoma cells. 

 

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TECHNICAL INFORMATION

Other Names: Torkinib

Chemical Formula: C16H16N6O

CAS Number: 1092351-67-1

Molecular Weight: 308.34

Purity:  >98%

Appearance:  a crystalline solid  

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%. 

References

Feldman et al. (2009) Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 7(2):e38.

Menendez et al. (2011) mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to stem cell renewal and aging. Cell Cycle. 10(21):3658-77.

Janes et al. (2010) Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med. 16(2):205-13.

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