TG101348

5mg

Cat. No.: 48-F21

$150.00

TG101348 is an ATP competitive Janus -associated kinase 2 (JAK2) inhibitor. It has has also been shown to inhibit Flt3 and Ret. It is not known to suppress any other kinases. It blocks the JAK2-driven STAT5 phosphorylation, cell proliferation and cell survival in JAK2V617F-expressing cell lines.

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TECHNICAL INFORMATION

Other Names: N-tert-Butyl-3-{5-methyl-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-pyrimidin-4-ylamino}-benzenesulfonamide

Chemical Formula: C27H36N6O3S

CAS Number: 936091-26-8

Molecular Weight: 524.68

Purity: >99%

IC50= 3nM

Appearance: Fine White

Solubility: DMSO (100mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 20mg/ml

References

Geyer | H.L. | et al (2012). Jak2 inhibitors and their impact in myeloproliferative neoplasm. Hematology. 1:S129-32.

Betts | B.C. | et al (2011). Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell-stimulated T cells yet preserves immunity to recall antigen. Blood. 118:5330-9.

Pardanani | A. et al (2011). Safety and efficacy of TG101348 | a selective JAK2 inhibitor | in myelofibrosis. J Clin Oncol. 29:789-96.

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