ZM447439

5mg

Cat. No.: 94-U12

$99.00

ZM447439 is a selective ATP-competitive inhibitor of Aurora B kinase. The Aurora kinases have important roles in regulating mitosis and cytokinesis, with Aurora B involved in centromere function as part of the Chromosomal Passenger Complex, with survivin, INCENP, and borealin. ZM447439 selectively inhibits proliferating cells rather than non-dividing cells, suggesting its potential in cancer therapy.

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TECHNICAL INFORMATION

Other Names: N-[4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]-benzamide

Chemical Formula: C29H31N5O4

CAS Number: 331771-20-1

Molecular Weight: 513.6

Purity: >99%

IC50= Aurora B: 50nM, Aurora C and A: 250 &1,000nM, CDK1, CDK2, CDK4, PLK1, CHK1, KDR2 & FAK: 10µM

Appearance: Off-White Crystalline Solid

Solubility: DMSO (25mg/ml)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 25mg/ml

References

Bedrick | B. | et al (2005). Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly | the completion of chromosome condensation | and the establishment of the spindle integrity check point in xenopus egg extracts. Mol. Biol. Cell. 16:1305-1318.

Walsby | E. | et al (2008). Effects if the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts. Haematologica. 93:662-9.

Ditchfield | C. | et al (2003). Aurora B couples chromosome alignment with anaphase by targeting BubR1 | Mad2 | and Cenp-E to kinetochores. J. Cell. Biol. 16:267-80.

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